Choosing the best cold sore creams in Japan at drugstores can be challenging, especially with language barriers and unfamiliar products. To assist you, we’ve compiled a list of cold sore creams and ointments available in Japan, including their dosages, price ranges, and active aciclovir content. 

Additionally, we’ve included information on cold sore patches as an alternative treatment option. Please note that this guide is for informational purposes only and should not replace professional medical advice. 

The pharmacists we spoke to highlighted that, unlike countries like the U.S. and the UK, you need a pharmacist present to buy cold sore creams or ointments in Japan. Regular drugstore employees can’t sell this medicine to you. As such, I find it best to avoid late evenings or lunchtime, as the pharmacist might be out to lunch or have already finished their shift.

Additionally, the main thing to look out for in any cold sore product is that it includes aciclovir as an active ingredient.

Always consult with a healthcare provider to determine the most appropriate treatment for your condition. Prices are approximate and may vary by location and retailer.

Aciclovir Cream (アシクロビルクリーム)

• Summary: Aciclovir cream is an antiviral medication used to treat cold sores by inhibiting the replication of the herpes simplex virus. It is commonly available in Japanese drugstores under various brand names, such as Arasena S Cream アラセナSクリーム and Herpecia Cream 2g (ヘルペシアクリーム2g) . See the images above for a reference to what these look like.
  
• Active Ingredient: Aciclovir (usually around 5%, 50 mg per gram of cream).
  
• Dosage: Apply a thin layer to the affected area five times a day at approximately four-hour intervals for at least four days. If the cold sore has not healed after ten days, consult a healthcare professional.
  
• Price Range: Varies per pharmacy and product. Approximately ¥1,000 to ¥1,500 for a 2g tube.
  
• Considerations: The drugstore staff we spoke to recommended starting treatment at the first sign of a cold sore, such as tingling or itching, for optimal effectiveness.

Aciclovir Ointment (アシクロビル軟膏)

• Summary: Although the phrase “cold sore cream” is more familiar and widely used in everyday English language, Japan distinguishes “ointments” and creams” based on the medicine. Both contain aciclovir as the active ingredient, but they differ in texture, application, and purpose.

• Ointment is thicker and oil-based, forming a protective barrier over the affected area to retain moisture and promote healing. This makes it ideal for use at night or when prolonged protection is necessary. In contrast, cold sore cream is lighter and water-based, absorbing quickly into the skin for a non-greasy feel. Creams are typically better suited for daytime application when comfort and convenience are priorities.
  
• Activir (アクチビア) is an example of a cold sore ointment popular in Japan.
  
• See the images above for a reference to what this looks like.
  
• Active Ingredient: Aciclovir (usually around 5%, 50 mg per gram of ointment).
  
• Dosage: Apply a thin layer to the affected area five times a day at approximately four-hour intervals for at least four days. If the cold sore has not healed after ten days, consult a healthcare professional.
  
• Price Range: Varies per pharmacy and product. Approximately ¥1,000 to ¥1,500 for a 2g tube.
  
• Considerations: The drugstore staff we spoke to recommended starting treatment at the first sign of a cold sore, such as tingling or itching, for optimal effectiveness.
  

Cold Sore Patches (ヘルペスパッチ)

• Summary: As someone who suffers from cold sores myself, I want to also share cold sore patches. I use these in cases where I’ve not been able to catch the cold sore in the initial “tingling phase”. It provides a protective barrier over the sore, promoting healing and reducing the risk of contamination. I also find that it helps prevent my skin from cracking further, helping with the pain.
  
• They are discreet and can be worn throughout the day. You can even apply makeup over them.
  While they are hard to find in drug stores and pharmacies in Japan, you can usually find them online at sites like idivia.com and Rakuten.
  
• Popular Brand: Compeed Invisible Cold Sore Discreet Healing Patch
  
• Usage: Apply the patch to clean, dry skin at the first sign of a cold sore. Note that if you’re using a cold sore cream or ointment first, the patch won’t stick. Replace the patch as needed, typically every 8 to 12 hours, until the sore has healed.
  
• Price Range: Approximately ¥1,200 to ¥1,800 for a pack of 15 patches.
  
• Considerations: Pharmacy staff mentioned that these patches are helpful for those seeking a discreet and hygienic option for cold sores once the sore has formed.

General Considerations

• Early Treatment: Initiating treatment at the first sign of a cold sore (such as tingling or itching) can significantly improve effectiveness.
• Application: Wash your hands before and after applying creams or patches to prevent the spread of infection.
  
• Consultation: If symptoms persist beyond ten days or worsen, seek medical advice.

This information is based on interviews with Japanese drugstore employees and available product data as of November 2024. Always read the product packaging and instructions carefully, and consult with a healthcare professional if you have any concerns or questions regarding treatment.

For more information, read our full guide to drugstores in Japan.

This page has been brought to you as a public service of the Yokohama Bluff Medical and Dental Clinic in Yokohama.