If you’re searching for the best eye drops in Japan, look no further. We’ve interviewed drugstore staff in Japan to round up which eye drops are most highly recommended for dry eyes and contact lenses. Prices listed are accurate as of January 2026 and don’t include sales tax. 

If dry eyes persist, they can increase the risk of infection and long-term vision damage, so consult an ophthalmologist if symptoms do not improve.

Down with the flu? Read our guide to Cold and Flu Medicine in Japan.

Good All-Round: Hyalein S

Summary: Hyalein S was the top product recommended by drugstore staff for dry eyes and contact lenses. Until recently, these eye drops were only available on prescription, but they are now widely available OTC in Japanese drugstores. The moisture-retaining formula, which contains 0.1% hyaluronic acid, provides treatment for dry eyes, eye fatigue and blurred vision. Unlike some eye drops, Hyalein S is safe with both soft and hard contact lenses. 

Price: Around ¥1,580 (5ml x 2)

Dosage: Apply 1 drop to 5 to 6 times daily. Do not let the applicator make contact with any part of your eye. 

Considerations:  If you plan to use Hyalein S for more than two weeks, it’s best to check with a doctor. Anyone with an existing eye condition, including dry eye or glaucoma, should also talk to a doctor before using it. Do not use Hyalein S if you experience sudden changes in vision or severe eye pain, and avoid using it with colored contact lenses.

Ideal for Dry Eyes: Sante Medical Plus Guard X

Summary: Drugstore staff recommended these eye drops for people with dry eyes, as well as other common eye issues. The formula contains seven active ingredients that help support corneal repair, reduce inflammation, and keep the eyes hydrated. It can be used to relieve eye strain, dryness, itchiness, and UV-induced inflammation, such as snow blindness, and is also suitable for easing irritation from hard contact lenses. 

Price: Around ¥1,480 (12ml)

Dosage: Apply 1 to 3 drops 5 to 6 times daily. Make sure the tip of the container doesn’t touch any part of your eye. 

Considerations: Consult a doctor if symptoms don’t improve after 5 to 6 days of using this medication. Anyone with a diagnosis of glaucoma and anyone experiencing severe eye pain should also speak to a doctor or pharmacist before use. These drops are not suitable for use while you’re wearing soft contact lenses. 

Best For Contact Lenses: Tearal Moisture Rich Serum

Summary: Drugstore staff particularly recommend Tearal Moisture Rich Serum for use with contact lenses. You can use these eye drops while wearing soft or hard contact lenses, O2-permeable lenses, and color contacts. The mineral-rich formula closely mimics natural tears to help relieve dry, tired eyes.

Price: Around ¥1,200 (13ml)

Dosage: Apply 2 to 3 drops 3 to 6 times a day. 

Considerations: People with glaucoma or eye pain should consult a doctor or pharmacist before using this product. 

Eye Drops in Japan FAQs

How do you say “contact lenses” in Japanese?
“Contact lenses” in Japanese is コンタクトレンズ (kontakuto renzu). In everyday conversation, you’ll often hear コンタクト (kontakuto).
Examples you might hear or use:
• ソフトコンタクト = soft contact lenses
• ハードコンタクト = hard contact lenses
• カラーコンタクト or カラコン = colored contact lenses
At drugstores, signs for contact lens-friendly eye drops often say コンタクト使用可 (safe for contact lens use).

Can I bring contact lenses into Japan?
Yes, you can bring contact lenses into Japan for personal use. You can bring disposable and reusable contact lenses in your luggage without special paperwork. For personal use, you can usually bring a reasonable supply, typically up to a few months’ worth. If you are bringing a large quantity, customs may question whether they are for resale. Contact lens solution is also OK, but liquids in carry-on luggage must follow airline size restrictions.

Are Japanese eye drops safe to use with contact lenses?
Many Japanese eye drops are safe to use with contact lenses, but not all of them. You can use Hyalein S and Tearal Moisture Rich Serum with both soft and hard contact lenses, including O2-permeable lenses. Sante Medical Plus Guard X, however, is not suitable to use while wearing soft contact lenses. Always check the label or ask a pharmacist before use.

Can I buy eye drops in Japan without a prescription?
Yes, most eye drops in Japan are available over the counter and you can buy them at drugstores without a prescription. Even products that were previously prescription-only, such as Hyalein S, are now widely available OTC. Instructions are usually in Japanese, so asking staff for help or using a translation app can be useful.

Do Japanese drugstores have staff who can help choose eye drops?
Yes, most Japanese drugstores have trained staff or pharmacists who can recommend eye drops based on your symptoms, including dryness, eye strain, or contact lens use. Many larger stores in urban areas can assist in simple English, especially in tourist-friendly locations.

Where can I buy eye drops in Japan?
You can buy eye drops at major Japanese drugstore chains such as Matsumoto Kiyoshi, Sundrug and Welcia. Prices may vary slightly by store and do not usually include sales tax.

For more information, read our full guide to drugstores in Japan.

This page has been brought to you as a public service of The Bluff Medical and Dental Clinic in Yokohama.